Not all individuals with CLL have to have therapy. Regardless of all modern innovations, the iwCLL even now endorses watchful observation for individuals with asymptomatic disorder.86 This recommendation is based on at the least two randomized trials evaluating observation to possibly chlorambucil monotherapy or fludarabine, cyclophosphamide and rituximab (FCR).103,104 Each trials concluded that early therapy in asymptomatic sufferers was not linked to a chronic In general survival.
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A spouse and children heritage is additionally the strongest danger variable for the event of CLL. The risk of creating CLL is about 8.five times bigger Should you have a first-degree relative with CLL. A primary-diploma relative might be a:
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プットが低下することが分かる． このことから，異なるトラフィック特性（ペイロードサ
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